DNA is a history book – a narrative of the journey of our species through time. A shop manual, with an incredibly detailed blueprint for building every human cell. It’s a transformative textbook of medicine, with insights. These insights give health care providers immense new powers to treat, prevent, and cure diseases.”

 

Genetics and Genomics

 

Gene study exists in 2 facets: genetics and genomics. Genetics is the study of single genes in isolation. Genomics is the study of all the genes in the genome, their interaction with each other, and with the environment. Each individual’s history book is full of possible stories. The stories tell of their influence by factors such as diet, lifestyle, emotional state, and environment.


In clinical practice, we are privileged to have the ability to hear what our patients are presenting with, or their story. We have the capacity to order testing to look at their phenotypical expression. The phenotypical expression describes what each gene is telling the body to say. In other words, the “stories” told. This allows not only to offer better treatment of existing concerns but also to tailor the prevention of future disease.

 

DNA: A Patient Study

 

I saw this first-hand through the story of one of my patients, JP. When we met, JP told me “I would love to find relief from the gut pain I feel daily… I can’t remember the last day I had without some bowel pain or issue like gas and bloating.” Alongside her severe digestive symptoms, JP expressed significant anxiety, fatigue toward the end of the day, fertility concerns, and cravings for sweets.


JP was a bright, young individual experiencing undue suffering every day. The issues left unresolved by conventional care were not only causing daily pain and discomfort but put JP at risk for developing serious illness in the future.  


To get to the root-cause of JP’s suffering, I ran the following tests:


Enterolab

This uncovered hidden celiac disease, as well as casein (dairy) intolerance.


MRT LEAP

This showed 35 “reds” and “yellows” (food sensitivities), suggesting severe intestinal permeability.


GI Stool Effects 

Showing SIBO (Small Intestinal Bacterial Overgrowth) and various medication intolerances.


Neurotransmitter Testing

Showing imbalances that could aggravate and perpetuate her anxiety.


Heart Rate Variability

Showed a stressed system in need of rest and relaxation.


ION Panel

Her ION revealed numerous nutritional imbalances. These allowed for exploration into ‘nutrigenomics’, or how these nutrient deficiencies and imbalances affected JP’s gene expression and determined her health. 

All of the above tests allowed for a greater understanding of the underlying imbalances that lead to JP’s debilitating symptoms. This allowed me to eliminate her lifelong digestive problems by cleaning up her gut, reducing her toxicity, balancing her hormones, and replenishing her nutrient depletions.

Her anxiety, however, began to worsen once her digestion improved. It was only in looking at her genome that I was able to finesse her diet and supplement program to heal her fully. 


23andMe DNA Gene Test

Prior to the deciphering of the human genome, humans believed that once we knew the code of life in our DNA, we would answer all the questions related to the origin of disease. In reality, we learned that rather than disease being locked-in as hardwired “stories” in our genome, these characteristics included in our genes are dynamic. Each gene is in a constant dance with our environment, lifestyle, diet, stress level, and physical activity (or lack thereof).


In running the 23andMe DNA gene test, we uncovered genetic inefficiencies in methylation, neurotransmitter sensitivity (mood management), and nutrient usage (explaining the nutritional imbalances). We received information so we could optimize her diet and realized how to reduce her risk for the mood disorders most of her close family suffered from. The ability to improve her addictive behavior around sweets, and greatly reduce the risk of her developing the chronic illnesses she was particularly susceptible to getting.  

Thanks to genomic testing, I was able to see where JP’s gene expression was hindering her healing journey. With that knowledge, we were able to build bridges where there were once roadblocks, and JP left my office with the gifts of vitality and robust health.

 

The Genomic Revolution and Paradigm Shift in Healthcare

 

“Our health and disease patterns are not hardwired by our genes, but are rather a consequence of the interaction of our genetic uniqueness with environmental factors.”

Jeffery Bland, PhD

 

Jeff Bland called this genomic revolution a paradigm shift in our model of healthcare from a deterministic, disease-centric model to a wellness-centric model. We assumed dominant and recessive traits were locked into our genes with no ability to change them. The assumption said that medicine existed to put a band-aid on symptoms and disease which we could not prevent or heal. Luckily, our new wellness-centric model asks not only “How do you get sick?”, but “How can you be well?”.


We are on a gigantic wave of a medical revolution, and genomics is at the heart of that wave. Let’s paddle out together and see where the riptides might be.

 

About the author:

Dr. Murfin is wholeheartedly focused on her life’s mission to help people heal and achieve extraordinary outcomes. She believes that health is more than merely the absence of disease. It is a total state of physical, mental, emotional, spiritual, and social wellbeing through the creation of a whole and meaningful life. Dr. Murfin leaves no stone unturned to determine the root cause of illness or imbalance.

 

Why are DHEA & Testosterone Important? 

 

Testosterone is a male hormone, right? True, but females need it just as much as males do, just in smaller amounts. Not only is necessary for a healthy libido and sexual satisfaction, but it is also essential for bone health, brain health, muscle health, and heart health. It needs to be in balance with the other female hormones, estrogen, and progesterone (sex steroids), thyroid hormones, as well as our major stress hormone, cortisol, in order to function optimally. The Androgen DHEA is a feel-good hormone. It gives one a feeling of well being, libido, good sleep, muscle strength, and exercise tolerance.

 

What are the common symptoms of DHEA deficiency? 

Common symptoms of DHEA deficiency include reduced sex drive, reduced sexual sensitivity, difficulty achieving orgasm, painful intercourse, low mood and excessive anxiety, poor coping ability, reduced muscle tone and strength, joint pain, back pain, dry skin, poor memory or concentration and urinary incontinence. The symptoms can overlap with hormonal and other medical conditions. Thus, androgen deficiency often goes under-diagnosed and is not often thought to be relevant in females.

 

Cortisol Steal

So where does it all go wrong and why are we seeing so many women, young and old, with deficiency these days? Cortisol steal. This is exactly what it sounds like. Cortisol is stealing the substrates that our sex steroids and DHEA need to be formed because it is being produced in excess. DHEA becomes depleted and because this is upstream from testosterone (and estrogen), these downstream hormones also become depleted. So it’s the stressed women that get more hormonal issues. It is not the hormones’ fault. They are just responding appropriately to other imbalances in the body. Why would you need to reproduce or have sex for that matter, if you are running away from a lion?

 

Cortisol Steal

 

Stress and Hormones

The body interprets internal and external stress as the same thing. It doesn’t know the difference between having a fight with someone vs candida overgrowth in the gut, for example. It responds by releasing cortisol and other stress hormones and neurotransmitters from the adrenal glands. When cortisol is produced in excess, the hypothalamus in the brain perceives a threat. It switches off signals to the adrenals and cortisol is no longer produced. Alongside this, high cortisol triggers DHEA release, which tries to balance the high cortisol. With DHEA and cortisol levels low, the patient experiences stage 3 adrenal fatigue. The new term for this is HPA axis dysfunction/ dysregulation. 

 

Replacing DHEA and Testosterone in Women

DHEA and testosterone can be replaced alone, or alongside each other in women. It should be ensured that the other female hormones are also optimal. In our practice, we prescribe bioidentical hormones, which are hormones that behave in an exact way as our own hormones. They are still laboratory-made but are chemically identical to our hormones. The bad rap that hormone replacement has is from synthetic hormones, which confuse our hormonal systems – like putting the wrong key into a lock. Testosterone is most often prescribed topically, or in certain cases intramuscularly/ subcutaneous. DHEA is most often prescribed sublingually or by mouth, but can also be given topically.

 

The key to safe hormone replacement is testing your levels (24 hour urine hormone is the best test for this, but blood levels can be used when resources are limited). Once on the treatment, levels should be monitored by an experienced health care professional in order to find the dose that is right for you. This can vary tremendously between women, depending on genetics, underlying factors that caused the hormone deficit and lifestyle (a very active woman requires more DHEA or testosterone, often). You can find your optimum dose by looking at your levels alongside your symptoms. 

 

What else can you do to improve your levels besides taking hormones?

Hormone replacement is not the only answer but in every case, should be done alongside root cause treatment and lifestyle changes. Hormone replacement does not fix the adrenals and other hormones. It is just another patch if done alone. Some women even feel worse on hormones, which tells us we need to work on these root causes.

 

Other Lifestyle Improvements

So what can you do to help these hormones in your day to day life? Your overall aim is to decrease inflammation and stress on the HPA axis.

 

Diet

An anti-inflammatory diet is a good place to start. Many hormone disturbances start in the gut, because of a constant onslaught of foods that increase inflammation, upregulate our immune system, change our microbiome, and impact our gut-brain connection. Sugar, carbohydrates, and dairy are big contributors to poor hormone health.

 

Exercise

Make sure you are getting exercise that is appropriate for your condition. Don’t run a marathon when your adrenals are shot.

 

Sleep

Make sure you get at least 7-8 hours of sleep each night. Good sleep hygiene is essential and your health care professional may recommend supplements and medications for this.

 

Stress Management

Make sure you are identifying and managing stress – we cannot always change our stressful circumstances but we can change how we perceive them and what we do every day to find our calm.

 

We recommend 2 books to find out more: The Hormone Handbook by Dr. Thierry Hertoghe; and, What You Must Know About Women’s Hormones: Your Guide to Natural Hormone Treatments for PMS, Menopause, Osteoporis, PCOS, and More by Dr. Pamela Wartian Smith.

 

About the author:

One of Dr. Michelle’s greatest passions in life is to help people help themselves. She understands that your current health tells a story and that when you have symptoms of disease, your body is already out of balance. She believes that we should not have to settle for anything other than our most vital self and that her job is to figure out how to put you back on track. To book an appointment with Dr. Michelle, contact [email protected]

What are Bioidentical Hormones and how can they help menopause symptoms? Millions of Canadian women experience troublesome and debilitating menopause symptoms. The inevitable hot flashes, fatigue, night sweats, vaginal dryness, and mood changes that come with the diagnosis. The World Health Organization has released estimates stating that by 2030, 1.2 billion women worldwide will be postmenopausal, as 25 million women go through menopause every year. For several years, hormone replacement therapy (HRT) was a great help to many suffering from menopause symptoms. HRT can increase the risk of serious health events, like breast cancer, and strokes. Fortunately, today bioidentical hormones are available. Let’s delve into some frequently asked questions about bioidentical hormone therapy, or BHT.

 

Bioidentical Hormones and Menopause
Bioidentical Hormone Therapy Can Help Menopause Symptoms

 

Frequently Asked Questions about Bioidentical Hormones for Menopause

 

What are Bioidentical Hormones?

Bioidentical hormones are sex hormones that come in the form of estrogens and progesterone. Your body produces hormones structured exactly the same on a molecular level. Bioidentical hormones come from soy and yam plants where Hormone Replacement Therapy (HRT) uses traditional hormones, usually isolated from animals, which is much riskier health-wise.

 

Are Bioidentical Hormones Effective?

Bioidentical hormones are highly effective and have helped millions of women. A 2016 study provided evidence that Bioidentical Hormone Therapy reduces hot flashes, and two separate studies in 2014 and 2011 showed that BHT helped with mood swings, night sweats, and irritability. An Australian study showed that 15 percent of Australian women in their fifties and sixties had taken or took bioidentical hormones.

 

How Do I Take Bioidentical Hormones?

You can take Bioidentical Hormone Therapy in a few different ways. It is available in pill form that you swallow or dissolve under your tongue or administered as a cream, patch, spray, or vaginal ring. Name-brand bioidentical prescriptions are available at pharmacies (Prometrium, Vagifem, Vivelle Dot, etc.). You may require the services of a compounding pharmacy for some of your bioidentical hormones.

 

Are Bioidentical Hormones An Absolute Necessity?

Bioidentical hormones are not absolutely necessary and only yourself and a knowledgeable doctor experienced in the use of BHT can decide if they’re right for you. Your decision should be based on an educated assessment of the risks versus the benefits. Under the guidance of our physicians, you may choose to use herbs and supplements, traditional HRT, or nothing at all to help with menopausal symptoms and transition.

 

Can You Stop Bioidentical Hormone Therapy?

Adverse events from BHT are rare. One study in 2013 found zero adverse events in a group of 75 women undergoing BHT. If you do have an adverse event, or simply decide to go completely natural with your menopause plan, you’ll be happy to know that it is possible to stop BHT at any time. It is always advisable to do this under our physicians’ guidance who will monitor with exams and blood tests and gradually wean you off BHT.

 

Functional Medicine & Menopause

 

At Linden & Arc Vitality Institute, our Functional Medicine physicians will guide you to find the right fit. Remember, most therapies are more effective with lifestyle changes. These include factors like increased activity level, a good diet, and nutritional support in the form of supplements. Our clinic provides counseling and support to help you maintain and strengthen your health, transition through menopause with minimal symptoms, and thoroughly enjoy these happy years of your life.

 

References:

https://www.ncbi.nlm.nih.gov/pubmed/23627249
https://www.ncbi.nlm.nih.gov/pubmed/27008039
https://www.ncbi.nlm.nih.gov/pubmed/27479272
https://www.ncbi.nlm.nih.gov/pubmed/24881343
http://www.health.harvard.edu/womens-health/what-are-bioidentical-hormones
https://www.ncbi.nlm.nih.gov/pubmed/21651797

 

About the author:

Dr. Murfin is wholeheartedly focused on her life’s mission to help people heal and achieve extraordinary outcomes. She believes that health is more than merely the absence of disease. It is a total state of physical, mental, emotional, spiritual, and social wellbeing through the creation of a whole and meaningful life. Dr. Murfin leaves no stone unturned to determine the root cause of illness or imbalance.